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Malignant Genitourinary System Neoplasm

MedGen UID:: 199685
•Concept ID:: C0751569
•: Neoplastic Process

Synonyms:

Cancer, Genito-urinary; Cancer, Genitourinary; Cancer, Urogenital; Cancers, Genito-urinary; Cancers, Genitourinary; Cancers, Urogenital; Genito urinary Cancer; Genito-urinary Cancer; Genito-urinary Cancers; Genitourinary Cancer; Genitourinary Cancers; Urogenital Cancer; Urogenital Cancers

Definition

A primary or metastatic malignant neoplasm that affects the genitourinary system. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant Genitourinary System Neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Disorder by Site
      - Disorder of the genitourinary system
        Genitourinary System Neoplasm
        Malignant Genitourinary System Neoplasm
        Genitourinary System Carcinoma
        Female Reproductive System Carcinoma
        Carcinoma of cervix
        Carcinoma of fallopian tube
        Endometrial carcinoma
        Ovarian carcinoma
        Vaginal carcinoma
        Vulvar carcinoma
        Male Reproductive System Carcinoma
        Epididymal adenocarcinoma
        Penile carcinoma
        Prostate carcinoma
        Recurrent Male Reproductive System Carcinoma
        Refractory Male Reproductive System Carcinoma
        Rete testis adenocarcinoma
        Seminal vesicle adenocarcinoma
        Metastatic Genitourinary System Carcinoma
        Advanced Genitourinary System Carcinoma
        Locally Advanced Genitourinary System Carcinoma
        Metastatic Bladder Carcinoma
        Metastatic Cervical Carcinoma
        Metastatic Endometrial Carcinoma
        Metastatic Fallopian Tube Carcinoma
        Metastatic Kidney Carcinoma
        Metastatic Ovarian Carcinoma
        Metastatic Penile Carcinoma
        Metastatic prostate carcinoma
        Metastatic Ureter Carcinoma
        Metastatic Urethral Carcinoma
        Metastatic Urothelial Carcinoma
        Metastatic Vaginal Carcinoma
        Metastatic Vulvar Carcinoma
        Urinary System Carcinoma
        Recurrent Urinary System Carcinoma
        Refractory Urinary System Carcinoma
        Renal carcinoma
        Renal Pelvis and Ureter Carcinoma
        Ureter carcinoma
        Urethral Carcinoma
        Urinary bladder carcinoma
        Urothelial carcinoma
        Malignant Urinary Tract Neoplasm
        Hereditary Malignant Urinary System Neoplasm
        Hereditary renal cell carcinoma
        Hereditary Wilms tumor
        Malignant tumor of kidney
        Childhood malignant kidney neoplasm
        Kidney Lymphoma
        Malignant Kidney Neoplasm Except Pelvis
        Malignant mixed epithelial stromal tumor of the kidney
        Malignant renal pelvis neoplasm
        Metastatic Malignant Neoplasm in the Kidney
        Nephroblastoma
        Peripheral Primitive Neuroectodermal Tumor of the Kidney
        Renal sarcoma
        Malignant tumor of ureter
        Metastatic Malignant Neoplasm in the Ureter
        Regional ureteric cancer
        Ureteral lymphoma
        Malignant tumor of urinary bladder
        Bladder lymphoma
        Bladder Malignant PEComa
        Bladder Melanoma
        Bladder sarcoma
        Metastatic Bladder Paraganglioma
        Metastatic Malignant Neoplasm in the Bladder
        Recurrent Malignant Bladder Neoplasm
        Metastatic Malignant Neoplasm in the Urinary System
        Metastatic Malignant Neoplasm in the Urethra
        Mucosal Melanoma of the Urinary System
        Urethral Melanoma
        Recurrent Malignant Urinary System Neoplasm
        Recurrent Kidney Wilms Tumor
        Recurrent Rhabdoid Tumor of the Kidney
        Refractory Malignant Urinary System Neoplasm
        Refractory Rhabdoid Tumor of the Kidney
        Urethra cancer
        Anterior urethra cancer
        Female urethral cancer
        Male urethral cancer
        Malignant Accessory Urethral Gland Neoplasm
        Posterior urethra cancer
        Regional Malignant Urethral Neoplasm
        Metastatic Malignant Genitourinary System Neoplasm
        Advanced Malignant Genitourinary System Neoplasm
        Advanced Malignant Female Reproductive System Neoplasm
        Metastatic Malignant Female Reproductive System Neoplasm
        Locally Advanced Malignant Female Reproductive System Neoplasm
        Mucosal Melanoma of the Genitourinary System
        Mucosal Melanoma of the Female Genital Tract
        Cervix melanoma
        Vaginal melanoma
        Vulvar melanoma
        Penile Mucosal Melanoma
        Recurrent Malignant Genitourinary System Neoplasm
        Recurrent Malignant Female Reproductive System Neoplasm
        Recurrent Extrarenal Rhabdoid Tumor of the Ovary
        Recurrent Female Reproductive System Carcinoma
        Recurrent Malignant Endocervical Neoplasm
        Recurrent Malignant Ovarian Granulosa Cell Tumor
        Recurrent Ovarian Carcinosarcoma
        Recurrent Ovarian Germ Cell Tumor
        Recurrent Uterine Corpus Cancer
        Recurrent Uterine Corpus Sarcoma
        Recurrent Malignant Male Reproductive System Neoplasm
        Recurrent Malignant Spermatic Cord Neoplasm
        Recurrent Malignant Testicular Germ Cell Tumor
        Recurrent Testicular Lymphoma
        Reproductive system cancer
        Female reproductive organ cancer
        Adenosarcoma
        Fallopian tube cancer
        Gestational choriocarcinoma
        Malignant Mixed Mesodermal (Mullerian) Tumor
        Mesonephric adenocarcinoma
        Mesonephric-Like Adenocarcinoma
        Ovarian cancer
        Placenta cancer
        Refractory Malignant Female Reproductive System Neoplasm
        Resectable Malignant Female Reproductive System Neoplasm
        Rete ovarii adenocarcinoma
        Undifferentiated Stromal Sarcoma
        Uterine cancer
        Uterine ligament cancer
        Vaginal cancer
        Vulva cancer
        Male reproductive organ cancer
        Epididymis cancer
        Malignant Seminal Vesicle Neoplasm
        Malignant tumor of prostate
        Malignant tumor of testis
        Paratesticular Leiomyosarcoma
        Paratesticular Liposarcoma
        Paratesticular Malignant Mesothelioma
        Paratesticular Rhabdomyosarcoma
        Paratesticular Squamous Cell Carcinoma
        Paratesticular Wilms Tumor
        Penile cancer
        Refractory Malignant Male Reproductive System Neoplasm
        Spermatic cord cancer
        Malignant Sex Cord-Stromal Tumor
        Malignant sex cord stromal tumor of ovary
        Malignant Testicular Sex Cord-Stromal Tumor

Professional guidelines

PubMed

Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

Oaknin A, Bosse TJ, Creutzberg CL, Giornelli G, Harter P, Joly F, Lorusso D, Marth C, Makker V, Mirza MR, Ledermann JA, Colombo N; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2022 Sep;33(9):860-877. Epub 2022 Jun 8 doi: 10.1016/j.annonc.2022.05.009. PMID: 35690222

Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.

Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888

Practice Bulletin No. 174: Evaluation and Management of Adnexal Masses.

American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology
Obstet Gynecol 2016 Nov;128(5):e210-e226. doi: 10.1097/AOG.0000000000001768. PMID: 27776072

See all (32062)

Recent clinical studies

Etiology

HIV-Associated Urogenital Malignancies.

Hentrich M, Pfister D
Oncol Res Treat 2017;40(3):106-112. Epub 2017 Feb 24 doi: 10.1159/000457130. PMID: 28253510

Lichen Sclerosus-Presentation, Diagnosis and Management.

Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363 Free PMC Article

Neonatal cancer.

Orbach D, Sarnacki S, Brisse HJ, Gauthier-Villars M, Jarreau PH, Tsatsaris V, Baruchel A, Zerah M, Seigneur E, Peuchmaur M, Doz F
Lancet Oncol 2013 Dec;14(13):e609-20. doi: 10.1016/S1470-2045(13)70236-5. PMID: 24275134

Pediatric urologic oncology.

Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841

Pediatric genitourinary tumors.

Buckley KS
Curr Opin Oncol 2012 May;24(3):291-6. doi: 10.1097/CCO.0b013e32835265c9. PMID: 22476187

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Diagnosis

Ano-uro-genital mucosal melanoma UK national guidelines.

Smith HG, Bagwan I, Board RE, Capper S, Coupland SE, Glen J, Lalondrelle S, Mayberry A, Muneer A, Nugent K, Pathiraja P, Payne M, Peach H, Smith J, Westwell S, Wilson E, Rodwell S, Gore M, Turnbull N, Smith MJF
Eur J Cancer 2020 Aug;135:22-30. Epub 2020 Jun 9 doi: 10.1016/j.ejca.2020.04.030. PMID: 32531566

HIV-Associated Urogenital Malignancies.

Hentrich M, Pfister D
Oncol Res Treat 2017;40(3):106-112. Epub 2017 Feb 24 doi: 10.1159/000457130. PMID: 28253510

Lichen Sclerosus-Presentation, Diagnosis and Management.

Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363 Free PMC Article

Pediatric urologic oncology.

Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841

Pediatric genitourinary tumors.

McLean TW, Castellino SM
Curr Opin Oncol 2008 May;20(3):315-20. doi: 10.1097/CCO.0b013e3282f8b053. PMID: 18391632

See all (179224)

Therapy

Genitourinary cancers updates: highlights from ASCO 2023.

Qin Q, Sheffield H, Taasan SM, Wang AZ, Zhang T
J Hematol Oncol 2023 Nov 21;16(1):112. doi: 10.1186/s13045-023-01511-8. PMID: 37990343 Free PMC Article

HIV-Associated Urogenital Malignancies.

Hentrich M, Pfister D
Oncol Res Treat 2017;40(3):106-112. Epub 2017 Feb 24 doi: 10.1159/000457130. PMID: 28253510

Cabozantinib in genitourinary malignancies.

Zhang T, Park SE, Hong C, George DJ
Future Oncol 2017 Apr;13(8):755-765. Epub 2016 Nov 15 doi: 10.2217/fon-2016-0358. PMID: 27842445

Immunotherapy in genitourinary malignancies.

Wattenberg MM, Fong L, Madan RA, Gulley JL
Curr Opin Urol 2016 Nov;26(6):501-7. doi: 10.1097/MOU.0000000000000331. PMID: 27471994 Free PMC Article

Lichen Sclerosus-Presentation, Diagnosis and Management.

Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363 Free PMC Article

See all (132063)

Prognosis

Worldwide trends in cervical cancer incidence and mortality, with predictions for the next 15 years.

Lin S, Gao K, Gu S, You L, Qian S, Tang M, Wang J, Chen K, Jin M
Cancer 2021 Nov 1;127(21):4030-4039. Epub 2021 Aug 9 doi: 10.1002/cncr.33795. PMID: 34368955

Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.

Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369 Free PMC Article

Cervical Cancer Prevalence, Incidence and Mortality in Low and Middle Income Countries: A Systematic Review.

Shrestha AD, Neupane D, Vedsted P, Kallestrup P
Asian Pac J Cancer Prev 2018 Feb 26;19(2):319-324. doi: 10.22034/APJCP.2018.19.2.319. PMID: 29479954 Free PMC Article

Lichen Sclerosus-Presentation, Diagnosis and Management.

Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363 Free PMC Article

Pediatric urologic oncology.

Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841

See all (145907)

Clinical prediction guides

Adaptive Immunity in Genitourinary Cancers.

Koti M, Bivalacqua T, Black PC, Cathomen T, Galsky MD, Gulley JL, Ingersoll MA, Kamat AM, Kassouf W, Siemens DR, Gao J
Eur Urol Oncol 2023 Jun;6(3):263-272. Epub 2023 Apr 15 doi: 10.1016/j.euo.2023.03.002. PMID: 37069029

Pathomics in urology.

Schuettfort VM, Pradere B, Rink M, Comperat E, Shariat SF
Curr Opin Urol 2020 Nov;30(6):823-831. doi: 10.1097/MOU.0000000000000813. PMID: 32881725

Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System).

Panebianco V, Narumi Y, Altun E, Bochner BH, Efstathiou JA, Hafeez S, Huddart R, Kennish S, Lerner S, Montironi R, Muglia VF, Salomon G, Thomas S, Vargas HA, Witjes JA, Takeuchi M, Barentsz J, Catto JWF
Eur Urol 2018 Sep;74(3):294-306. Epub 2018 May 10 doi: 10.1016/j.eururo.2018.04.029. PMID: 29755006 Free PMC Article

The PROMIS of MRI.

Ahmed HU
BJU Int 2016 Jul;118(1):7. doi: 10.1111/bju.13547. PMID: 27311545

Pediatric genitourinary tumors.

Merguerian PA
Curr Opin Oncol 2003 May;15(3):222-6. doi: 10.1097/00001622-200305000-00008. PMID: 12778016

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Recent systematic reviews

2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review.

Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV
Eur Urol 2023 Aug;84(2):191-206. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.04.021. PMID: 37202314 Free PMC Article

Systematic review and meta-analysis of prediction models used in cervical cancer.

Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501

Radiotherapy of oligometastatic prostate cancer: a systematic review.

Rogowski P, Roach M 3rd, Schmidt-Hegemann NS, Trapp C, von Bestenbostel R, Shi R, Buchner A, Stief C, Belka C, Li M
Radiat Oncol 2021 Mar 9;16(1):50. doi: 10.1186/s13014-021-01776-8. PMID: 33750437 Free PMC Article

EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.

Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724

Surgery Versus Radiotherapy for Clinically-localized Prostate Cancer: A Systematic Review and Meta-analysis.

Wallis CJD, Saskin R, Choo R, Herschorn S, Kodama RT, Satkunasivam R, Shah PS, Danjoux C, Nam RK
Eur Urol 2016 Jul;70(1):21-30. Epub 2015 Dec 15 doi: 10.1016/j.eururo.2015.11.010. PMID: 26700655

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Malignant Genitourinary System Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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